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Chronic rhinosinusitis with multiple nasal polyps

MedGen UID:
1829866
•Concept ID:
C4524092
•
Disease or Syndrome
Synonyms: Chronic rhinosinusitis with nasal polyposis; Chronic rhinosinusitis with nasal polyps; CRSwNP - chronic rhinosinusitis with nasal polyps
SNOMED CT: Chronic rhinosinusitis with multiple nasal polyps (1285576009); Chronic rhinosinusitis with nasal polyposis (1285576009); Chronic rhinosinusitis with nasal polyps (1285576009); CRSwNP - chronic rhinosinusitis with nasal polyps (1285576009)

Professional guidelines

PubMed

The Joint Task Force on Practice Parameters GRADE guidelines for the medical management of chronic rhinosinusitis with nasal polyposis.
Rank MA, Chu DK, Bognanni A, Oykhman P, Bernstein JA, Ellis AK, Golden DBK, Greenhawt M, Horner CC, Ledford DK, Lieberman J, Luong AU, Orlandi RR, Samant SA, Shaker MS, Soler ZM, Stevens WW, Stukus DR, Wang J, Peters AT
J Allergy Clin Immunol 2023 Feb;151(2):386-398. Epub 2022 Nov 9 doi: 10.1016/j.jaci.2022.10.026. PMID: 36370881
Yardstick for the medical management of chronic rhinosinusitis.
Borish L, Baroody FM, Kim MS, Lieberman JA, Peters A, Stevens WW, Bernstein JA
Ann Allergy Asthma Immunol 2022 Feb;128(2):118-128. Epub 2021 Oct 20 doi: 10.1016/j.anai.2021.10.014. PMID: 34687874
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Recent clinical studies

Etiology

Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.
Oykhman P, Paramo FA, Bousquet J, Kennedy DW, Brignardello-Petersen R, Chu DK
J Allergy Clin Immunol 2022 Apr;149(4):1286-1295. Epub 2021 Sep 17 doi: 10.1016/j.jaci.2021.09.009. PMID: 34543652
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps.
Klingler AI, Stevens WW, Tan BK, Peters AT, Poposki JA, Grammer LC, Welch KC, Smith SS, Conley DB, Kern RC, Schleimer RP, Kato A
J Allergy Clin Immunol 2021 Apr;147(4):1306-1317. Epub 2020 Dec 14 doi: 10.1016/j.jaci.2020.11.037. PMID: 33326802Free PMC Article
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Diagnosis

Recent guidelines addressing chronic rhinosinusitis with nasal polyps: practical aspects.
Rank MA, Wonnaparhown AM, Freeman CM
Pol Arch Intern Med 2023 Nov 29;133(11) Epub 2023 Nov 21 doi: 10.20452/pamw.16611. PMID: 37987636
Managing Chronic Rhinosinusitis with Nasal Polyps in the Elderly: Challenges and Solutions.
Merrill T, Kanaan A
Clin Interv Aging 2022;17:685-698. Epub 2022 May 2 doi: 10.2147/CIA.S279765. PMID: 35535364Free PMC Article
Allergic Rhinitis.
Kakli HA, Riley TD
Prim Care 2016 Sep;43(3):465-75. doi: 10.1016/j.pop.2016.04.009. PMID: 27545735
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Therapy

New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis.
Striz I, Golebski K, Strizova Z, Loukides S, Bakakos P, Hanania NA, Jesenak M, Diamant Z
Clin Sci (Lond) 2023 May 18;137(9):727-753. doi: 10.1042/CS20190281. PMID: 37199256Free PMC Article
Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.
Oykhman P, Paramo FA, Bousquet J, Kennedy DW, Brignardello-Petersen R, Chu DK
J Allergy Clin Immunol 2022 Apr;149(4):1286-1295. Epub 2021 Sep 17 doi: 10.1016/j.jaci.2021.09.009. PMID: 34543652
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
Allergic Rhinitis.
Kakli HA, Riley TD
Prim Care 2016 Sep;43(3):465-75. doi: 10.1016/j.pop.2016.04.009. PMID: 27545735
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Prognosis

Endotyping Difficult-to-Treat Chronic Rhinosinusitis with Nasal Polyps by Structured Histopathology.
Cui Y, Wang K, Shi J, Sun Y
Int Arch Allergy Immunol 2023;184(10):1036-1046. Epub 2023 Jun 16 doi: 10.1159/000530864. PMID: 37331342
Prognostic factors for post-operative outcomes in chronic rhinosinusitis with nasal polyps: a systematic review.
Cai S, Lou H, Zhang L
Expert Rev Clin Immunol 2023 Jul-Dec;19(8):867-881. Epub 2023 May 27 doi: 10.1080/1744666X.2023.2218089. PMID: 37225659
A review of current biomarkers in chronic rhinosinusitis with or without nasal polyps.
Nakayama T, Haruna SI
Expert Rev Clin Immunol 2023 Jul-Dec;19(8):883-892. Epub 2023 Apr 7 doi: 10.1080/1744666X.2023.2200164. PMID: 37017326
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477

Clinical prediction guides

Correlation between inflammatory biomarkers and disease control in chronic rhinosinusitis with nasal polyps.
De Corso E, Baroni S, Settimi S, Onori ME, di Cesare T, Mastrapasqua RF, Sarlo F, Penazzi D, D'Agostino G, D'Auria LM, De Maio G, Fetoni AR, Galli J
Int Forum Allergy Rhinol 2024 Jul;14(7):1195-1205. Epub 2024 Jan 24 doi: 10.1002/alr.23319. PMID: 38266634
Prognostic factors for post-operative outcomes in chronic rhinosinusitis with nasal polyps: a systematic review.
Cai S, Lou H, Zhang L
Expert Rev Clin Immunol 2023 Jul-Dec;19(8):867-881. Epub 2023 May 27 doi: 10.1080/1744666X.2023.2218089. PMID: 37225659
Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.
Oykhman P, Paramo FA, Bousquet J, Kennedy DW, Brignardello-Petersen R, Chu DK
J Allergy Clin Immunol 2022 Apr;149(4):1286-1295. Epub 2021 Sep 17 doi: 10.1016/j.jaci.2021.09.009. PMID: 34543652
Anti-interleukin 5 therapy for chronic rhinosinusitis with polyps.
Poblete MJ, Rosenbaum A, Winter M
Medwave 2018 Oct 24;18(6):e7301. doi: 10.5867/medwave.2018.06.7300. PMID: 30365483
Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study.
Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S
Allergy 2015 Aug;70(8):995-1003. Epub 2015 May 26 doi: 10.1111/all.12644. PMID: 25945591Free PMC Article

Recent systematic reviews

Prognostic factors for post-operative outcomes in chronic rhinosinusitis with nasal polyps: a systematic review.
Cai S, Lou H, Zhang L
Expert Rev Clin Immunol 2023 Jul-Dec;19(8):867-881. Epub 2023 May 27 doi: 10.1080/1744666X.2023.2218089. PMID: 37225659
Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.
Oykhman P, Paramo FA, Bousquet J, Kennedy DW, Brignardello-Petersen R, Chu DK
J Allergy Clin Immunol 2022 Apr;149(4):1286-1295. Epub 2021 Sep 17 doi: 10.1016/j.jaci.2021.09.009. PMID: 34543652
Effect of monoclonal antibodies on olfactory dysfunction caused by chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.
Tsetsos N, Markou K, Konstantinidis I
Int Forum Allergy Rhinol 2020 Jul;10(7):893-900. Epub 2020 May 29 doi: 10.1002/alr.22576. PMID: 32250544
Monoclonal antibodies for the treatment of chronic rhinosinusitis with nasal polyposis: a systematic review.
Tsetsos N, Goudakos JK, Daskalakis D, Konstantinidis I, Markou K
Rhinology 2018 Mar 1;56(1):11-21. doi: 10.4193/Rhino17.156. PMID: 29396960
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Dinarte VRP, Santos ARDD, Araújo LF, Reis MGAD, Tamashiro E, Valera FCP, Silva Júnior WAD, Anselmo-Lima WT
Braz J Otorhinolaryngol 2017 Nov-Dec;83(6):705-711. Epub 2017 Mar 23 doi: 10.1016/j.bjorl.2017.03.002. PMID: 28400178Free PMC Article

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